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showed that supplementation with Bifidobacterium longum NCC3001 (BL) at a dose of 1 10 10 CFU/day for 4 weeks improves depression-like symptoms (reduced BDI-II score by 3.2 points) and quality of life (increased IBS-QoL score by 15%) in IBS patients with comorbid depressive symptoms ( Summary of core mechanisms: dietary fiber increased abundance of gut microbiota ( Bifidobacterium / Lactobacillus ) enhanced SCFA production mood regulation via the gut-brain axis alleviation of depressive symptoms (Figure 2)

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