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It could be a little redness or swelling, which is often normal and goes away quickly
This timing allows tissues to return to normal temperature before the next application
Under the influence of IL-4 and IL-13 and the interactions between adhesion molecules on B cells (class II MHC molecules: CD80/CD86, CD40, and ICAM-1) and T cells (CD3, CD4, CD28, CD40L, and LFA-1 receptors), B cells switch from expressing IgM, IgG2, and IgG3 to IgG4 and IgE (179)
There is no drug without any side effects but the physician always weighs in the risk- benefit ratio before prescribing one as should be the case