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Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models

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- Cardiac glycosides: May increase the possibility of arrhythmias or increase digitalis toxicity associated with hypokalemia

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For the AOD-9604 deep dive, see What Is AOD-9604