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Mutational analysis revealed key residues (R63, F64, W65, H71, R72, G73, R80) crucial for enzyme function, despite not directly binding the substrate

The scale of its clinical program, the magnitude of its effects, and its proven cardiovascular benefit represent a genuine step-change in what pharmacotherapy for obesity can achieve

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

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As you lose weight, your energy expenditure decreases, so maintaining a deficit requires eating less than before