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Specifically, we suggest that the benzyl portion of the isobenzopyrrole-1,3-dione moiety of CP17 might be modified to provide groups able to make polar or charge interactions with the carbonyl oxygen of VP1-Ile89 or the carboxylate of the sidechain of VP1 Asp114 (Fig

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Once the cargo is selected, the autophagosomes undergo maturation

Alterations in mitochondrial biogenesis may result in decreased mtDNA levels, triggering complex cellular responses that particularly affect genes related to the cell cycle and mitochondrial functions (Mineri et al