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Drug Metab Rev 1998, 30 (2), 245275

SLC7A5 expression is regulated by ATF4 (ATF4 is a known transcriptional activator of ASNS expression) under low leucine conditions via the GAAC pathway and by c-Myc through direct promoter binding, while HIF-2 enhances SLC7A5-mediated mTORC1 phosphorylation (161)

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In the Phase 2 obesity data the weight curve was still trending downward at 48 weeks, so a genuine plateau at a tolerated maintenance dose may simply reflect the body settling toward a new set point rather than the protocol failing