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Contraindications include personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, pancreatitis history, severe GI or kidney disease, pregnancy, and breastfeeding

Therefore, the findings of the subgroup analysis have to be interpreted cautiously and further investigations are needed to assess whether GLP-1RA may reduce the incidence of arrhythmias in patients with multiple comorbidities

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Intermittent maternal hypoxia has an influence on regional expression of endothelial nitric oxide synthase in fetal arteries of rabbits