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On average, patients lose 14.9% of their starting body weight over 68 weeks on semaglutide 2.4 mg weekly, according to the STEP 1 trial

However, severe gastrointestinal side effects such as persistent vomiting or diarrhoea may indirectly lead to electrolyte disturbances through dehydration

This triple mechanism distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

The National Institute for Health and Care Excellence (NICE) provides guidance on the use of GLP-1 receptor agonists, including semaglutide, as part of a comprehensive diabetes management strategy