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IS: Writing original draft, Writing review & editing, Conceptualization

Semaglutide interacted with circumventricular organs, where GLP-1R expression is abundant, and with regions protected by the BBB (lateral septal nucleus, nucleus tractus solitarius, hypothalamic arcuate nucleus) (102)

doi: 10.1111/j.1532-5415.2008.02051.x [DOI] [PubMed] [Google Scholar] 50

It is composed of the amino acids glutamine, cysteine and glycine, and is found in the highest levels in the liver, eyes, spleen, pancreas and kidneys

York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, OMalley BW