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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Pasqualotto E, Ferreira RO, Chavez MP, et al

Second, the arginine at position 3 in the native sequence was substituted with leucine (hence R3)

The most commonly reported adverse events are gastrointestinal reactions, including nausea, vomiting, diarrhea, and constipation, which typically occur during the early phase of treatment and tend to diminish or resolve with continued therapy (55, 56)

This characteristic is particularly significant for treating central nervous system disorders, where systemic drug administration is often ineffective