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Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

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Unlike trigeminal neuralgia, which involves short (seconds to minutes) episodic, sharp, electric-like pain affecting one or more branches of the trigeminal nerve, CTN often manifests as continuous pain or sensory disturbances [1]

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