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Data from in vivo study also revealed that a high-fat diet accelerates the proliferation of prostate tumors and increased M2/M1 macrophage ratio and myeloid-derived suppressor cells fraction via interleukin (IL)-6/phospho-signal transducer and activator of transcription 3 (pSTAT3) signaling [43]

However, GPX3 expression is elevated in epithelial ovarian cancer (OC) and clear cell carcinoma of the ovary (3)

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Inhibition of mTOR with rapamycin or RNA interference promoted the formation of memory CD8 + T cells in an LCMV infection model [193]

6 Clinical research and future perspectives 6.1 Expansion trends in clinical indications At present, the most established clinical applications of riboflavin are in FAD responsive metabolic disorders such as RTD and MADD