(2021) 10:e63538
Role of Nrf2 in oxidative stress and toxicity
DrBL: Yeah, its definitely an upstream factor
Hook., Prunus persica (L.) Batsch, Solanum lycopersicum L., Sorghum bicolor (L.) Moench, Vitis vinifera L., and Zea mays L., all found in the Phytozome v.10.3 database (Goodstein et al., to confirm the protein domain families (Finn et al., Analysis of GPX and APX genes/proteins Physicochemical properties of GPX and APX proteins were determined by using ProtParam tool (Gasteiger et al., 2006) and WoLF PSORT (Horton et al., GPX/APX genes was analyzed by using a GSDS server (Hu et al., 1994) and phylogenies were constructed by MEGA 6 (Tamura et al., 2013) with the maximum likelihood (ML) method for 1.000 bootstraps
Redox balance therefore depends on cellular NADPH-generating pathways, with the oxidative pentose phosphate pathway often making a major contribution and other pathways contributing in a cell- and context-dependent manner