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Typical treatment schedules include: Initial treatment: frequent injections for severe deficiency Maintenance therapy: injections every 23 months Healthcare professionals must always follow clinical guidelines and patient-specific treatment plans

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The first step of glutathione synthesis involves the formation of glutamylcysteine from glutamate and cysteine in an ATP dependent reaction catalysed by glutamate-cysteine-ligase (GCL) which requires either Mg 2+ or Mn 2+ as a cofactor