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they promote vasodilation by enhancing NOS activity, promoting NO production, increasing cyclic guanosine monophosphate (cGMP) levels, maintaining NO-cGMP pathway activity, down-regulating arginase II protein expression, and reducing competitive consumption of L-arginine

Vion AC, Perovic T, Petit C, Hollfinger I, Bartels-Klein E, Frampton E, Gordon E, Claesson-Welsh L, Gerhardt H (2021) Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways