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In longer studies, around half of the participants lost 15% of their body weight at 68 weeks, and nearly a third lost 20%

*Contraindications weight loss injections include a personal or family history of medullary thyroid cancer, allergy to GLP-1 and weight loss injections, Type 1 Diabetes or history of Diabetic Ketoacidosis, personal or family history of Multiple Endocrine Neoplasia, personal history of Pancreatitis, renal impairment or kidney disease, gallbladder disease, or concurrent use of anti-diabetic medications or insulin

When oxygen availability is limited, glucose is the most metabolically efficient fuel, and during myocardial ischemia, the ratio of acetyl-CoA/CoA in mitochondria increases, leading to the activation of pyruvate dehydrogenase (PDH) kinase, which in turn phosphorylates PDH to inhibit its activity

Mechanism 2: Slowed Gastric Emptying Where It Works: GLP-1 receptors in your stomach and intestines

this is explored in more depth below