In a phase 3 clinical trial, Zepbound led to an average weight loss of 22.5% body weight, or about 52 pounds, surpassing all currently available weight loss medications on the market
Who Should Start GLP-1 Treatment and How Genetics May Inform Provider Conversations GLP-1 medications are appropriate for adults with a BMI 30 or 27 with weight-related comorbidities (hypertension, type 2 diabetes, cardiovascular disease), provided no contraindications exist
The neurologists agreed in suggesting physical activity at the first visit, particularly aerobic and strength training
This makes it easier for people to eat less and pick healthier foods
In contrast, GLP-1 RAs exert their effects through weight reduction, enhancement of insulin sensitivity, modulation of lipogenesis, and regulation of the gut-liver axis