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The related modulatory mechanisms namely regulating Hadhb-mediated FAO, the Sirt1/NF-kB signaling pathway, and mTORC2/PPAR-g signaling and other pathways are involved [72, 73]

The majority of caregivers reported that patients experienced hyperphagia (68%) and half of patients experienced obesity (52%)

In research contexts, DSIP is referenced in preclinical and exploratory studies examining peptide signalling, molecular interactions, and biochemical pathways under controlled laboratory conditions

TangCAhmedKGilleALuSGroneHJTunaruSet al

Moreover, each group has rather balanced numbers of biomarker-positive patients, which further supports the discrepancy was mostly due to the misdiagnosis