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93 In IPF, abnormally activated Wnt signalling is detected, which manifests as follows: significantly increased expression of Wnt1, Wnt7b, Wnt10b, FZD2, FZD3, -catenin, and LEF1 in the lung tissue, thereby promoting fibroblast proliferation and epithelial cell-mesenchymal transition, the pathological process of IPF

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Variations in ACL size, shape, and insertion points can affect the distribution and activity of these growth factors, impacting the ligaments ability to repair and adapt to mechanical loading