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The combination of liraglutide and anti-PD-1 can enhance the cytotoxicity of CD8 + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7

The investment will support a Phase IIa clinical study of CSTI-500 in individuals with PWS, expected to begin in 2026

The creatine and GLP-1 guide covers the evidence base and practical use

Florentin M, Elisaf MS, Rizos CV, et al

These may be appropriate for patients at higher nutritional risk or those recovering from illness