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The glucagon receptor component is hypothesised based largely on preclinical and early clinical observations to increase energy expenditure and promote fat breakdown (lipolysis), which may offer additional metabolic benefits

It is not an approved dietary supplement ingredient under the Dietary Supplement Health and Education Act (DSHEA) framework because it has not been grandfathered in as a pre-DSHEA ingredient and is not a recognized vitamin, mineral, herb, or botanical

Nature Genet

Gastrointestinal side effects associated with Zepbound, particularly nausea and vomiting, may occasionally trigger autonomic responses including diaphoresis (sweating)