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The trial included over 3,400 people with a BMI of 30 or above (or 27+ with at least one weight-related health condition) and without type 2 diabetes
Originally developed for type 2 diabetes, these medications have shown remarkable efficacy in promoting substantial weight loss and even cardiovascular benefits, leading to widespread use
Some users notice altered bowel movements (3-6%), ranging from slightly looser to slightly firmer stools during the initial 1-2 weeks
However, human studies are limited, and clinical significance remains uncertain compared to lifestyle interventions
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