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Injectable GLP-1-based therapies, including semaglutide and tirzepatide, have demonstrated substantial benefits for weight loss and cardiometabolic risk reduction ( 1 3 ), but real-world uptake has been shaped by factors such as route of administration, access, tolerability, and insurance coverage ( 4 7 )

Study limitations Although the current findings are consistent and coherent, strongly indicating the external validity of the study, we do recommend future preferably large prospective clinical trials, to increase their internal validity

Companion actives, working doses, and evidence notes

December 8, 2023

Then you realize what happened and start worrying about what all that extra semaglutide is doing in your system