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PubMed Central, doi:10.1111/andr.12498

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It causes the separation of DNA strands and by inserting itself between DNA base pairs, it disrupts DNA and RNA synthesis, thereby stalling the movement of topoisomerase II, leading to DNA damage and initiation of apoptosis (Johnson-Arbor et al., 2017)

For example, a compound that targets the brain, like nicotinamide riboside (NR), will complement a compound that targets the rest of the body, like exenatide