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Research has identified several contributing mechanisms: dysregulated innate immune signalling, oxidative stress from reactive oxygen species damaging skin cells, and impaired barrier function that leaves the skin more reactive to triggers it would otherwise tolerate

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Similarly, systemic TB-500 administration in rats, dogs, and primates was well tolerated up to 60 mg/kg intravenously, with no histopathological abnormalities reported

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Companies should choose partners based on their professional skills, how well they follow regulations, and how willing they are to work together to support growth goals from the study phase to the commercialization phase