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Studies examining copper ions show they provide up to 90% inhibition of type 1 5-alpha reductase at 0.12 micrograms per milliliter, offering 50% reduction in activity

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In the phase 3 ACHIEVE-3 trial , adults with type 2 diabetes inadequately controlled by metformin were randomized to receive orforglipron or oral semaglutide (7 mg and 14 mg, doses approved for type 2 diabetes)

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