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A study in the European Review for Medical and Pharmacological Sciences found that B12 injections lowered the need for painkillers in patients suffering from sciatic nerve pain

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Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12