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Clinical studies indicate that TB-500 exhibits systemic distribution after subcutaneous injection, with therapeutic concentrations detectable in multiple organ systems within 24 hours of administration

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Likewise, this is also with the additional pressure increase in the superior sagittal sinus (where the severe portal and caval hypertension were not further raised by venous hypertension additionally originated within neck (venography into the right jugular vein), or abdomen (venography into the inferior caval vein))