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To test the effects of BGJ398 on the activity of Fgfrs in the retina, we performed a Phos-tag Western blot analysis and observed that the Ick substrate Kif3a was more phosphorylated in the retina of BGJ398-treated Mak / mice than in that of vehicle-treated Mak / mice, suggesting that Ick is activated by BGJ398 in the Mak / retina (Fig 4K and L)

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