doi: 10.1038/d41586-022-00382-2 102 MontoyaJGKogelnikAMBhangooMLunnMRFlamandLMerrihewLEet al
However, these adaptive endocrine changes, when prolonged, are associated with a reduced metabolic rate and impaired growth in severely malnourished children [38,39,40] Recent studies report significantly lower free T3, free T4, TSH and serum albumin levels in SAM as compared to moderate acute malnutrition (MAM), with strong, positive correlations between albumin and thyroid hormones [32, 34, 41] Nonetheless, findings on TSH remain inconsistent, as some studies showed no differences between SAM and MAM [32, 33, 36] while others reported significantly higher [42] or lower [41, 43] levels in SAM
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Instead of drinking large amounts at once, sip water consistently throughout the day
The medical management of these patients is therefore focused on altering brain and CNS neurochemistry
