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Interestingly, we also detected a similar association between the other incretin receptor, glucose-dependent insulinotropic polypeptide receptor (GIPR), and endogenous SPHKAP following GIP stimulation of INS-1 832/3 cells stably expressing SNAP/FLAG-hGIPR (Supplementary Fig

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic beta-Catenin, PIK3CA and MET

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Glycemic control and insulin sensitivity

The FDA approved tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity, or adults who are overweight and have at least one weight-related condition, in addition to reduced-calorie eating and increased physical activity