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Set appropriate follow-up based on expected mechanism timelines

No adverse effects were reported, confirming the compounds good tolerability

A low-dose GLP-1 approach may help reduce common side effects, such as nausea and digestive discomfort, especially for people who are sensitive to GI changes

To investigate the physiological functions of endogenous GLP-1 mediated via vagal sensory neurons, a rat model with vagal sensory neuron-specific GLP-1R knockdown was generated by microinjecting a viral vector expressing GLP-1R shRNA into the nodose ganglion [51]

MOTS-c activates specific cellular pathways that stimulate the breakdown of glucose and fat while simultaneously increasing the cells sensitivity to insulin