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In two of the studies, patients were taking oral antidiabetic drugs in addition to L-carnitine treatment, glyburide, and metformin in one paper,[] the results of which indicated an increment in TG, Apo A, and Apo B and no changes in LDL-C, HDL-C, and TC, and metformin and sulfonylurea in another study,[] the results of which showed significant reductions in FBS levels

Cancer Manag Res , 6 , 317328

Although these studies do not specifically differentiate between neuronal and astrocytic contributions, it is possible that the modulation of astrocytic A 1 and A 2A receptors may have an impact on the onset and progression of ALS, given the well-established importance of astrocytes in the disease [435]

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