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The vitamin's water-soluble nature means excess amounts are readily excreted through urine, reducing the risk of accumulation

thetaiotaomicron (Supplementary Fig

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Acknowledgments We would like to acknowledge the staff and patients involved in the study at the Department of Internal Medicine, Section for Gastroenterology, and the Department of Laboratory Medicine and Pathology at Haukeland University Hospital

Mean (SD) half-life of CT-388 was 134.6 (21.95) and 151.2 (22.24) hours for 8 mg and 22 mg, respectively, supporting once-weekly dosing