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These computational findings are consistent with experimental and preliminary clinical evidence, including observational studies and randomized clinical trials, suggesting that metformin may reduce the risk of AD and comorbid AD in individuals with DM2 while also enhancing cognitive performance 52,53,54,55,56,57

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The data representing turnover numbers in min 1 have been extracted from the following references: a (Dixon et al., b (Dixon and Edwards, c (Lallement et al., 2014)

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