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More than 10% of the synthesized GSH is found in mitochondria, where it reacts with ROS and prevents apoptosis

Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

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Also, the absolute and fractional synthesis rates did not correlate with fasting glucose or HbA1c (Figs 2B and 3B