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The 60-day minimum is risk mitigation in the absence of human pregnancy pharmacokinetics, not a guarantee of complete biological clearance of all downstream effects.

The current medical consensus, in one line Berberine is a legitimate natural compound with modest, mostly blood-sugar-related benefits, and it is not a substitute for prescribed medication

Alcohol also promotes inflammation, contributing to longer recovery times and increased pain

Considering the variability introduced by hormonal fluctuations such as estrogen, only male mice were used to ensure experimental uniformity