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First clinical trial to investigate the efficacy and safety of combined SGLT2 inhibitor and GLP-1R agonist therapy in patients with T2DM, suggesting additive or synergistic effects on weight loss

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(2024) demostraron que el GLP-1 puede aumentar la frecuencia cardaca en reposo de forma directa, actuando sobre los receptores en el nodo sinusal, incluso sin participacin del sistema nervioso autnomo

However, treatment decisions should always involve coordination between the patient's primary care team and gastroenterology specialist, as the complexity of managing two conditions simultaneously requires integrated clinical oversight