The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations
Subsequent clinical double-blind controlled trials indicated that multi-dose flavonoid regimens (200800 mg daily) were safe, well-tolerated, and without significant accumulation, supporting the potential of flavonoid-based supplements in PD management (Pang et al., 2016)
However, the success of your routine depends on bioavailability
Research has shown reduced melanin levels compared to placebo groups, though results vary based on metabolism, dosage, and absorption
Full details of these analyses are included in Supplementary file 5