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Abbreviations Bya Billion years ago CAT Catalase C P Peroxidatic cysteine C R Resolving cysteine DAMPs Damage associated molecular patterns DASP Deacon active site profiler ER Endoplasmic reticulum ERO1 ER oxidoreductase 1 GOE Great oxidation event GPX Glutathione peroxidase GSH Glutathione H 2 O 2 Hydrogen peroxide LCAA Last common animal ancestor O 2 - Superoxide anion radical PDI Protein disulfide isomerase PRX Peroxiredoxin ROS Reactive oxygen species SRX Sulfiredoxin Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made