A large retrospective cohort study revealed that T2DM patients treated with GLP-1RAs exhibited a significantly reduced risk of developing dementia compared with those receiving other glucose-lowering therapies.126 In a clinical trial involving cognitively intact individuals aged 4570 years at risk for AD, liraglutide administration for 12 weeks enhanced intrinsic connectivity within the default mode network as measured by resting-state functional magnetic resonance imaging, although no significant cognitive improvements were observed during the study period.127 In patients with mild cognitive impairment and AD, an 18-month course of exenatide was well tolerated but did not yield significant changes in clinical or cognitive outcomes or in most neuroimaging or biomarker assessments, except for a reduction in plasma neuronal extracellular vesicle A42 levels, potentially reflecting systemic neuronal status
L Glutathione vs Glutathione vs S Acetyl Glutathione L-Glutathione (Reduced Glutathione) is the active form, and oxidised Glutathione (GSSG) is the inactive state, which is recycled
Practical stress interventions that evidence supports include a 10-minute daily walking practice, progressive muscle relaxation before bed, limiting caffeine after noon, and reducing screen time in the hour before sleep
If you are already taking omeprazole for established reflux disease, continue as prescribed unless your doctor advises otherwise
Erichsen JM, Calva CB, Reagan LP, Fadel JR (2021) Physiology & Behavior Intranasal insulin and orexins to treat age-related cognitive decline
