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BPC-157 attenuated the decreased threshold in an early time (2 h after incision) but this effect disappeared thereafter

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It leads to reduced T cell proliferation and diminished cytokine production such as IL-2 and IFN- [307, 308], a condition seen in aged individuals as well [309, 310], resulting in an increased susceptibility to infections

LTB4, leukotriene B4

This does not necessarily increase therapeutic benefit proportionally because tissue binding sites saturate