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The PNMT gene is located on chromosome 17q12 and is composed of 4 exons that generate two alternatively spliced mRNAs, one of which is non-coding, the other encodes the functional protein of 282 amino acids

In a recent work by Charbord et al., a novel method using a luminescence ubiquitination-based cell cycle indicator (LUCCI) in zebrafish was employed to discover HG-991-01 as a driver for cellular proliferation, which was subsequently verified in both mouse and human beta cells (Wagner 2022

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