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Small human trials have not revealed significant toxicity, but they also lack rigorous design and long-term surveillance
The gut hormones cholecystokinin (CCK), fibroblast growth factor 19 (FGF19) and glucagon-like peptide 2 (GLP-2) are known to regulate gallbladder motility, and changes in postprandial concentrations of these hormones could explain the altered gallbladder motility
The International Sports Science Association (ISSA) announced a new training package designed specifically for people taking GLP-1s for weight loss
Weight loss drugs approved by the FDA since 2012 include: Foundayo (orforglipron) Zepbound (tirzepatide) Wegovy / Wegovy HD (semaglutide) Saxenda (liraglutide) Contrave (bupropion and naltrexone) Qsymia (phentermine and topiramate) In addition to weight loss in adults, Zepbound is approved to treat moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity
TABLE 1 Clinical characteristics at baseline
