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References Staresinic M, Sebecic B, Patrlj L, et al
Over-the-counter remedies that may help If lifestyle changes aren't enough, there are safe over-the-counter options to consider: Osmotic laxatives like polyethylene glycol (Miralax) draw water into the bowel to soften stool Magnesium citrate works similarly and is often recommended by experts for GLP-1-related constipation Stool softeners like docusate sodium can make stools easier to pass without stimulating the intestines Fiber supplements can help, but start with a low dose and increase gradually while drinking plenty of water Talk to your doctor or dietitian before trying any supplements
This is important for both research and clinical translation, as it shifts the focus from observing disease to understanding the biological pathways behind it
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