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The carriers of the loss-of-function GIP receptor variants, R190Q and E288G, display higher blood pressure and an increased tendency toward hypertension (99) but a comprehensive study of larger number of loss-of-function GIP receptor variants did not reveal similar effects on cardiovascular traits (39)

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Weight reduction ranged from -]5.1% (6 mg) to -9.6% (36 mg) , versus -2.5% with placebo

Sirtuin 6 Inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling