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Among covered workers in firms with 200 or more workers, 13% contribute less than $500 a year for single coverage, while 23% have a contribution of $2,000 or more [Figure 6.13]

But as evidence propositions they are worlds apart: one is an FDA-approved drug with replicated Phase 3 trials, the other is an unapproved research chemical with two small surrogate-marker studies and discontinued development

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This limitation hinders comparisons of AE risk between tirzepatide and other GLP-1 receptor agonists

Fatty acid accumulation causes insulin resistance through insulin signaling cascades, which counteracts increased glucose uptake and glycolysis 46