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Goldman says that your stool may be pale or clay colored

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Emotional symptoms Women with PMS may feel low or irritable, but for women with PMDD, the emotional symptoms are much more distressing and can include severe depression, overwhelming anxiety, extreme irritability, and mood swings that feel out of control

67 It is, however, intriguing to observe that in gut pathologies, especially related to the colon and including chronic inflammatory conditions, claudin-1 protein expression is markedly upregulated (and mislocalized)

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