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This method allows your skin to reap the full rewards of tretinoin, while the moisturizer acts as a buffer, reducing the risk of irritation (Source)

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doi: 10.1007/s13668-020-00313-5 282 RiberaCSnchez-OrtJVClarkeGMarxWMrklSBalanz-MartnezV

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The spacing is important: PPC-induced cell lysis triggers a local inflammatory response that must resolve before the next session treating before clearance is complete reduces results