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But those criteria would make 3.4 million patients eligible for the drug in England alone

10.1016/j.molcel.2017.05.032 32 GentileF.ArcaroA.PizzimentiS.DagaM.CetrangoloG

412 Despite these above factors, evidences persist that endothelial dysfunction, oxidative stress, and vitamin D deficiency are important in the glucose intolerance pathogenesis and IR in patients with CKD

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[15] [16] Cuando se usa con insulina o sulfonilureas, existe mayor riesgo de hipoglucemia, por lo que puede ser necesario ajustar estas medicaciones